Feyenoord will take a narrow lead to the San Siro for the second leg of their Champions League play-off round tie after the Dutch side held out for 1-0 win at home to AC Milan.
The only goal of the game in the third minute when Igor Paixao cut in from the left and saw his speculative low drive sneak past Mike Maignan at the near post.
Milan drew a blank in response to leave them with work to do in their home fixture.
Club Brugge edged Atalanta 2-1 at the Jan Breydel Stadium, downing the Serie A side with a fiercely-contested injury-time penalty.
Isak Hien was punished for a coming together with his Sweden team-mate Gustaf Nilsson, sparking complaints from the visiting side.
Nilsson dusted himself down to slot home the spot-kick. Brugge, who scraped the final spot in the play-offs by finishing in 24th place, had taken the lead through Ferran Jutgla on the quarter-hour before Mario Pasalic levelled heading into the break.
Benfica will take a 1-0 lead back to Lisbon after seeing off 10-man Monaco.
After a first-half stalemate, a deft chip from Vangelis Pavlidis put the away team ahead just after the restart. A second yellow card for Moatasem Al-Musrati further undermined the Ligue 1 side’s efforts and they were unable to get back into the contest.